Discovery

خلاصہ: How a common immunosuppressive drug injures liver blood vesselsIn a human organoid-based mechanistic investigation, researchers revealed how an immunosuppressive drug, antithymocyte globulin (ATG), induces injury to blood vessels in the liver. According to the study, ATG first triggers rapid clotting through a complement activation system and later causes inflammation by activating the TGF-β pathway. This discovery explains why some patients experience severe liver-related side effects following organ transplantation, and the research may aid in the development of safer immunosuppressive regimens.Source InformationPublisher: Medical Xpress - latest medical and health news storiesOriginal Source: Read more

خلاصہ: MDGA2 gene malfunction removes brain's excitatory 'brake' to trigger severe epilepsy, study findsThe DGIST Center for Synapse Diversity and Specificity has identified MDGA2 as a novel causative gene for developmental and epileptic encephalopathy (DEE), a rare and intractable neurological disorder occurring in infancy and early childhood. This study advances the understanding of the causes of DEE and highlights the potential for early diagnosis and the development of new therapies.Source InformationPublisher: Medical Xpress - latest medical and health news storiesOriginal Source: Read more

خلاصہ: Single-shot HIV vaccine candidate induces neutralizing antibodies for the first timeScientists at The Wistar Institute have developed an HIV vaccine candidate that achieves something never before observed in the field: inducing neutralizing antibodies against HIV after a single immunization in nonhuman primates. The innovative approach, published in Nature Immunology, could significantly shorten and simplify HIV vaccination protocols, making them more accessible worldwide.Source InformationPublisher: Medical Xpress - latest medical and health news storiesOriginal Source: Read more

خلاصہ: Scientists just mapped the hidden structure holding the Universe togetherAstronomers have produced the most detailed map yet of dark matter, revealing the invisible framework that shaped the Universe long before stars and galaxies formed. Using powerful new observations from NASA’s James Webb Space Telescope, the research shows how dark matter gathered ordinary matter into dense regions, setting the stage for galaxies like the Milky Way and eventually planets like Earth.Source InformationPublisher: All Top News -- ScienceDailyOriginal Source: Read more

خلاصہ: This brain discovery is forcing scientists to rethink how memory worksA new brain imaging study reveals that remembering facts and recalling life events activate nearly identical brain networks. Researchers expected clear differences but instead found strong overlap across memory types. The finding challenges decades of memory research. It may also help scientists better understand conditions like Alzheimer’s and dementia.Source InformationPublisher: All Top News -- ScienceDailyOriginal Source: Read more

خلاصہ: A 20-year-old cancer vaccine may hold the key to long-term survivalTwo decades after a breast cancer vaccine trial, every participant is still alive—an astonishing result for metastatic disease. Scientists found their immune systems retained long-lasting memory cells primed to recognize cancer. By enhancing a key immune signal called CD27, researchers dramatically improved tumor elimination in lab studies. The findings suggest cancer vaccines may have been missing a crucial ingredient all along.Source InformationPublisher: All Top News -- ScienceDailyOriginal Source: Read more

خلاصہ: Tiny mammals are sending warning signs scientists can finally readSmall mammals are early warning systems for environmental damage, but many species look almost identical, making them hard to track. Scientists have developed a new footprint-based method that can tell apart nearly indistinguishable species with remarkable accuracy. Tested on two types of sengi, the system correctly identified them up to 96% of the time. It offers a simple, ethical way to monitor ecosystems before they quietly unravel.Source InformationPublisher: All Top News -- ScienceDailyOriginal Source: Read more

خلاصہ: A breakthrough that turns exhaust CO2 into useful materialsScientists have created a device that captures carbon dioxide and transforms it into a useful chemical in a single step. The new electrode works with realistic exhaust gases rather than requiring purified CO2. It converts the captured gas into formic acid, which is used in energy and manufacturing. The system even functions at CO2 levels found in normal air.Source InformationPublisher: All Top News -- ScienceDailyOriginal Source: Read more

خلاصہ: Scientists turn tumor immune cells into cancer killersScientists at KAIST have found a way to turn a tumor’s own immune cells into powerful cancer fighters—right inside the body. Tumors are packed with macrophages, immune cells that should attack cancer but are usually silenced by the tumor environment. By injecting a specially designed drug directly into tumors, researchers were able to “reprogram” these dormant cells to recognize and destroy cancer.Source InformationPublisher: All Top News -- ScienceDailyOriginal Source: Read more

خلاصہ: These nanoparticles could destroy disease proteins behind dementia and cancerResearchers have developed smart nanoparticles that can seek out and destroy disease-causing proteins the body can’t normally eliminate. Unlike traditional drugs, these particles can reach hard-to-access tissues, including the brain, and precisely target problem proteins without widespread side effects. Early results show promise against major cancer drivers, and the platform is designed to be easily adapted to many diseases. The work could reshape the future of precision medicine.Source InformationPublisher: All Top News -- ScienceDailyOriginal Source: Read more

خلاصہ: Dark stars could solve three major mysteries of the early universeJWST has revealed a strange early universe filled with ultra-bright “blue monster” galaxies, mysterious “little red dots,” and black holes that seem far too massive for their age. A new study proposes that dark stars—hypothetical stars powered by dark matter—could tie all these surprises together. These exotic objects may have grown huge very quickly, lighting up the early cosmos and planting the seeds of supermassive black holes.Source InformationPublisher: All Top News -- ScienceDailyOriginal Source: Read more

خلاصہ: The hidden reason cancer immunotherapy often failsCancer immunotherapy has been a game-changer, but many tumors still find ways to slip past the immune system. New research reveals a hidden trick: cancer cells can package the immune-blocking protein PD-L1 into tiny particles that circulate through the body and weaken immunotherapy’s impact. Scientists in Japan discovered that a little-known protein, UBL3, controls this process—and surprisingly, common cholesterol-lowering drugs called statins can shut it down.Source InformationPublisher: All Top News -- ScienceDailyOriginal Source: Read more

خلاصہ: Why long COVID brain fog seems so much worse in the U.S.A massive international study of more than 3,100 long COVID patients uncovered a striking divide in how brain-related symptoms are reported around the world. In the U.S., the vast majority of non-hospitalized patients described brain fog, depression, and anxiety, while far fewer patients in countries like India and Nigeria reported the same issues. The difference doesn’t appear to be about the virus itself, but about culture, stigma, and access to mental health care.Source InformationPublisher: All Top News -- ScienceDailyOriginal Source: Read more

خلاصہ: Scientists “resurrect” ancient cannabis enzymes with medical promiseScientists have uncovered how cannabis evolved the ability to make its most famous compounds—THC, CBD, and CBC—by recreating ancient enzymes that existed millions of years ago. These early enzymes were multitaskers, capable of producing several cannabinoids at once, before evolution fine-tuned them into today’s highly specialized forms. By “resurrecting” these long-lost enzymes in the lab, researchers showed how cannabis chemistry became more precise over time—and discovered something unexpected: the ancient versions are often more robust and easier to work with.Source InformationPublisher: All Top News -- ScienceDailyOriginal Source: Read more

خلاصہ: One protein may decide whether brain chemistry heals or harmsTryptophan does far more than help us sleep—it fuels brain chemistry, energy production, and mood-regulating neurotransmitters. But as the brain ages or develops neurological disease, this delicate system goes awry, pushing tryptophan toward harmful byproducts linked to memory loss, mood changes, and sleep problems.Source InformationPublisher: All Top News -- ScienceDailyOriginal Source: Read more